个人介绍
2021.8-至今，中国科学院化学研究所，有机固体实验室，研究员（博导）
2018.12-2021.6，香港科技大学(HKUST)，化学及生物工程学系, 博士后，合作导师：唐本忠
2017.11-2018.11，加州大学洛杉矶分校(UCLA)，化学与生物分子工程系，博士后，合作导师：Yunfeng Lu
2012-9至2017-7，中国科学院化学研究所，有机固体实验室，博士，导师：王树
2008-9至2012-7，湖南大学，化学化工学院，学士，导师：蒋健晖
研究方向：共轭分子体系的生物电子应用。基于共轭分子体系结构可定制、组装可调控、功能可编程的特色与优势，通过可控生物自组装体系的设计和构筑，精准调控生物电子过程，发展基于共轭分子的新型生物活性材料体系及其智能电子器件，在生物功能调控、生物功能增强和生物功能创制等方面开展系列研究工作。
综述论文
Organic Semiconductor-Organism Interfaces for Augmenting Natural and Artificial Photosynthesis
Acc. Chem. Res., 2022, 55, 156-170.
Organic Semiconducting Polymers for Augmenting
Biosynthesis and Bioconversion
JACS Au, 2023, 4, 3-19.
Water-soluble conjugated polymers for bioelectronic Systems
Mater. Horiz., 2023, 10, 1210-1233.
Sensing, imaging and therapeutic strategies endowing
by conjugate polymers for precision medicine
Adv. Mater. 2024, 20231032.
Conjugated polymers for biomedical applications
Chem. Commun. 2022, 58, 7232-7244.
研究成果-2024
1. Rational Design of Conjugated Polymers for Photocatalytic CO2 Reduction：Towards Localized CO Production and Macrophage Polarization, Zhu, Chuanwei (co-first author); Cheng, Junjie (co-first author); Lin, Hongrui; Yang, Zhiwen; Huang, Yiming; Lv, Fengting; Bai, Haotian*; Wang, Shu*, J. Am. Chem. Soc. 2024, accepted.
2. Regulation of cell membrane potential through supramolecular system for activating calcium ion channel, Song, Gang; Li, Boying; Yang, Zhiwen; Lin, Hongrui; Cheng, Junjie; Huang, Yiming; Xing, Chengfen*; Lv, Fengting*; Bai, Haotian*; Wang, Shu*, J. Am. Chem. Soc. 2024, accepted.
3. Sensing, imaging and therapeutic strategies endowing by conjugate polymers for precision medicine, Qi Shen, Gang Song, Hongrui Lin, Haotian Bai,* Yiming Huang, Fengting Lv* and Shu Wang*, Adv. Mater. 2024, 20231032.
4. Organic Semiconducting Polymers for Augmenting Biosynthesis and Bioconversion, Chen Weijian, Lin Hongrui, Yu Wen; Huang, Yiming; Lv, Fengting, Bai Haotian* and Wang Shu*, JACS Au, 2023, 4, 3-19.
5. Utilizing Microbial Metabolite in Catalytic Cascade Synthesis of Conjugated Oligomers for In-Situ Regulation of Biological Activity, Yuke Li, Yiming Huang*, Qi Shen, Wen Yu, Zhiwen Yang, Zhiqiang Gao, Fengting Lv, Haotian Bai* and Shu Wang*, Bioorganic Chemistry, 2024, 145, 107188.
研究解读
1. Artificial Bacterial "Factory" Created to Synthesize Proteins More Efficiently
2. Researchers Develop Solar-Powered Multi-Organism Symbiont Mimic System for Beyond Natural Synthesis of Polypeptides from CO2 and N2
3. 人工光合生物工厂：构建有机半导体-微生物组装系统用于太阳光驱动的化学品合成成
4. 可控光催化反应用于裂解NAD+并促进乏氧肿瘤细胞凋亡
5. 基于活体材料的生物电子器件用于监测乳酸和肿瘤细胞
6. Researchers Develop Flexible Bioelectronic Device Based Living Material for Monitoring Lactate and Tumor Cells
研究成果-2023
1. Unexpected Photocatalytic Degeneration of NAD+ for Inducing Apoptosis of Hypoxia Cancer Cells, Shengpeng Xia, Haotian Bai*, Endong Zhang, Wen Yu, Zhiqiang Gao, Fengting Lv,Yiming Huang*, Daoben Zhu, Shu Wang*, CCS Chem., 2023,5, 2324-2333.
2. Solar-Powered Multi-Organism Symbiont Mimic System for Beyond Natural Synthesis of Polypeptides from CO2 and N2, Wen Yu, Yue Zeng, Zenghao Wang, Shengpeng Xia, Zhiwen Yang, Weijian Chen, Yiming Huang, Fengting Lv, Haotian Bai* Shu Wang*, Sci. Adv., 2023, 9, eadf6772.
3. Increased Nitrogenase Activity in Solar-Driven Biohybrids Containing Non-photosynthetic Bacteria and Conducting Polymers, Yue Zeng, Haotian Bai*, Wen Yu, Shengpeng Xia, Qi Shen, Yiming Huang, Fengting Lv, Guillermo C. Bazan* and Shu Wang*, Angew. Chem. Int. Ed. 2023, e202303877.
4. Nitrogen Fixation with Bacteria Biohybrids, Miaomiao Zhang, Wen Yu, Fengting Lv, Yiming Huang, Haotian Bai*, Shu Wang* Joule, 2023, 7, 1943-1974.
5. Water-Soluble Conjugated Polymers for Bioelectronic Systems, Zenghao Wang, Hongrui Lin, Miaomiao Zhang, Wen Yu, Chuanwei Zhu, Pengcheng Wang, Yiming Huang, Fengting Lv, Haotian Bai*, Shu Wang* Mater. Horiz., 2023, 10, 1210-1233.
6. Biophotonic Device Based on Conjugated Polymer and Macrophage-Laden Hydrogel for Triggering Immunotherapy, Zhiwen Yang, Qi Shen, Longjiang Xing, Xuancheng Fu, Zhipeng Qiu, Hongping Xiang, Yiming Huang, Fengting Lv, Haotian Bai,* Yanping Huo* and Shu Wang*, Mater. Horiz., 2023,10, 2226-2236.
7. Conjugated Molecules Based Multi-Component Artificial Photosynthesis System for Producing Multi-Objective Products, Chuanwei Zhu, Zhiqiang Gao, Wen Yu, Shengpeng Xia, Weijian Chen, Gang Song, Yiming Huang, Fengting Lv, Haotian Bai*, Shu Wang*, Small, 2023, 2306440.
8. Photosynthetic Polymer Dots-Bacteria Biohybrid System Based on Transmembrane Electron Transport for Fixing CO2 into Poly-3-hydroxybutyrate, Wen Yu, Mariia V. Pavliuk, Aijie Liu, Yue Zeng, Shengpeng Xia, Yiming Huang, Haotian Bai,* Fengting Lv, Haining Tian* and Shu Wang*, ACS Appl. Mater. Interfaces, 2023, 15(1), 2183-2191.
9. Self-Powered Biohybrid Systems Based on Organic Materials for Sustainable Biosynthesis, Weijian Chen, Wen Yu, Zenghao Wang, Zhiqiang Gao, Miaomiao Zhang, Chuanwei Zhu, Fengting Lv, Yiming Huang, Haotian Bai,* Shu Wang*, ACS Appl. Mater. Interfaces, 2023, DOI: 0.1021/acsami.3c12400.
研究成果-2022
1. Flexible Bioelectronic Device Fabricated by Conductive Polymer-Based Living Materials, Zenghao Wang, Haotian Bai*, Wen Yu, Zhiqiang Gao, Weijian Chen, Zhiwen Yang, Chuanwei Zhu, Yiming Huang, Fengting Lv, Shu Wang*, Sci. Adv., 2022, 8, eabo1458a.
2. Organic Semiconductor-Organism Interfaces for Augmenting Natural and Artificial Photosynthesis, Xin Zhou, Yue Zeng, Fengting Lv, Haotian Bai*, Shu Wang*, Acc. Chem. Res., 2022, 55, 156-170.
3. Solar-Driven Producing of Value-Added Chemicals with Organic Semiconductor-Bacteria Biohybrid System, Wen Yu, Haotian Bai*, Yue Zeng, Hao Zhao, Shengpeng Xia, Yiming Huang, Fengting Lv, Shu Wang*, Research, 2022, 9834093.
4. Conjugated Polymers for Biomedical Applications, Hongrui Lin, Haotian Bai*, Zhiwen Yang, Qi Shen, Mingyu Li, Yiming Huang, Fengting Lv, Shu Wang*, Chem. Commun. 2022, 58, 7232-7244. (Invited Feature Article)
5. 基于导电高分子-叶绿体杂化材料活性氧增强策略的肿瘤治疗, 袁海涛#，申奇#，于汶，曾悦， 白昊天,* 黄一鸣, 吕凤婷, 王树,*《高分子学报》2022, 53, 1251-1260. ("超分子专刊"约稿)
研究成果-2021
1. Functionalization of Silk by AIEgens through Facile Bioconjugation: Full-Color Fluorescence and Long-Term Bioimaging, Chenchen Liu, Haotian Bai*, Benzhao He, Xuewen He, Jianyu Zhang, Chao Chen, Yanping Qiu, Rong Hu, Fangxin Zhao, Yunxiao Zhang, Wei He, Joe H.C.Chau, Sijie Chen, Jacky W.Y. Lam, BenZhong Tang*, Angew. Chem. Int. Ed., 2021, 60,12424-12430.
2. Water-Soluble Organic Nanoparticles with Programable Intermolecular Charge Transfer for NIR-II Photothermal AntiBacterial Therapy, Shuang Tian#, Haotian Bai#, Shengliang Li*, Yafang Xiao, Xiao Cui, Xiaozhen Li, Jihua Tan, Zhongming Huang, Dong Shen, Weimin Liu, Pengfei Wang, Ben Zhong Tang*, ChunSing Lee*, Angew. Chem. Int. Ed., 2021, 60, 11758-11762.
3. Augmenting Photosynthesis Through Facile AIEgen-Chloroplast Conjugation and Efficient Solar Energy Utilization, Haotian Bai#, Haixiang Liu#, Xu Chen#, Rong Hu, Meng Li, Wei He, Jian Du, Zhiyang Liu,* Anjun Qin, Jacky W Y Lam, Ryan T K Kwok*, Ben Zhong Tang*, Mater. Horiz., 2021, 8, 1433-1438.
4. A Biocompatible Dual-AIEgen System Without Spectral Overlap for Quantitation of Microbial Viability and Monitoring of Biofilm Formation, Wei He#, Zheng Zheng#, Haotian Bai*, Ling-Hong Xiong, Lei Wang, Yinghui Li, Ryan T. K. Kwok, Jacky W. Y. Lam, Qinghua Hu, Jinquan Cheng*, Ben Zhong Tang*, Mater. Horiz., 2021, 8, 1816.
5. AIEgens for Microbial Detection and Antimicrobial Therapy, Haotian Bai#, Wei He#, Joe H.C. Chau, Zheng Zheng, Ryan T.K. Kwok, Jacky W. Y. Lam, Ben Zhong Tang*, Biomaterials, 2021, 268, 120598.
http://www.sciencedirect.com/science/article/pii/S0142961220308449 6. Boosting Cyanobacteria Growth by Fivefold with AggregationInduced Emission Luminogens: Toward the Development of a Biofactory, Haixiang Liu#, Haotian Bai#, Neng Yan#, Tin Yan Wong, Dongfeng Dang, Jen-Shyang Ni, Jacky W. Y. Lam, Henry Lam, Ryan T. K. Kwok*, Wen-Xiong Wang*, Ben Zhong Tang*, ACS Sustainable Chem. Eng., 2021, 9, 15258-15266.
7. Design of Functional Polymer Nanomaterials for Antimicrobial Therapy and Combatting Resistance, Zelin Li#, Haotian Bai#, Shaochuan Jia, Huanxiang Yuan*, Li-Hua Gaoa, Haiyan Liang, Mater. Chem. Front., 2021, 5,1236.
研究成果-2015~2020
2020年
1. Multifunctional Supramolecular Assemblies with Aggregation-Induced Emission (AIE) for Cell Line Identification, Cell Contamination Evaluation, and Cancer Cell Discrimination, Haotian Bai, Zhiyang Liu, Tianfu Zhang, Jian Du, Chengcheng Zhou, Wei He, Joe H. C. Chau, Ryan T. K. Kwok, Jacky W. Y. Lam, Ben Zhong Tang*, ACS Nano, 2020, 14, 7552-7563.
2. Antibiotic Modification Addressing Resistance, Haotian Bai, Shu Wang, Antibiotic Drug Resistance, John Wiley & Sons, Inc.,2020, 16. 407-428.
2019年
1. Supramolecular Antibacterial Materials for Combatting Antibiotic Resistance, Xingshu Li#, Haotian Bai#, Yuchong Yang#, Juyoung Yoon,* Shu Wang,* Xi Zhang,* Adv. Mater., 2019, 31, 1805092.
2. Luminescent, Oxygen-Supplying, Hemoglobin-Linked Conjugated Polymer Nanoparticles for PhotodynamicTherapy, Linye Jiang, Haotian Bai, Libing Liu*, Fengting Lv, XueqinRen*, ShuWang*, Angew.Chem.Int.Ed., 2019, 58,10660-10665.
3. Amine-Responsive Cellulose-Based Ratiometric Fluorescent Materials for Real-Time and Visual Detection of Shrimp and Crab Freshness, Ruonan Jia, Weiguo Tian, Haotian Bai, Jinming Zhang*, Shu Wang*, Jun Zhang*, Nat. Commun., 2019,10,795.
2018年
1. Supramolecular Strategy Based on Conjugated Polymers for Discrimination of Virus and Pathogens, Haotian Bai, Huan Lu, Xuancheng Fu, Endong Zhang, Fengting Lv,* Libing Liu, Shu Wang*, Biomacromolecules, 2018, 19, 2117-2122.
2. Electrochemiluminescence for Electric-Driven Antibacterial Therapeutics, Shanshan Liu, Huanxiang Yuan, Haotian Bai, Pengbo Zhang, Fengting Lv, Libing Liu, Zhihui Dai*, Jianchun Bao, Shu Wang*, J. Am. Chem. Soc.,2018, 140, 2284-2291.
2015-2017年
1. Supramolecular Antibiotic Switch for Antibacterial Regulation, Haotian Bai, Huanxiang Yuan, Chenyao Nie, Bing Wang, Fengting Lv*, Libing Liu, Shu Wang*, Angew. Chem. Int. Ed., 2015, 54, 13208-13213.
2. Supramolecular Conjugated Polymer Naterials for in Situ Pathogen Detection, Haotian Bai, Hui Chen, Rong Hu, Meng Li, Fengting Lv,* Libing Liu, Shu Wang*, ACS Appl. Mater. Interfaces, 2016, 8, 31550-31557.
3. Supramolecular Antibiotic Switches: A Potential Strategy for Combating Drug Resistance, Haotian Bai, Fengting Lv*, Libing Liu, Shu Wang*, Chem. Eur. J., 2016, 22,11114-11121.
4.Supramolecular Conjugated PolymerSystems with Controlled Antibacterial Activity, Haotian Bai, Hongyi Zhang, Rong Hu, Hui Chen, Fengting Lv*, Libing Liu, Shu Wang*, Langmuir, 2017, 33, 1116-1120.
5. Supramolecular Germicide Switches through Host-Guest Interactions for Decelerating Emergence of Drug-Resistant Pathogens, Haotian Bai, Xuancheng Fu, Zehuan Huang, Fengting Lv, Libing Liu, Xi Zhang, Shu Wang, ChemistrySelect, 2017, 2, 7940-7945.
研究成果图文信息
Rational Design of Conjugated Polymers for Photocatalytic
CO2 Reduction：Towards Localized CO Production and
Macrophage Polarization
Flexible bioelectronic device fabricated by conductive polymer–based living material
Unexpected Photocatalytic Degeneration of NAD+ for
Inducing Apoptosis of Hypoxia Cancer Cells
Biophotonic Device Based on Conjugated Polymer and
Macrophage-Laden Hydrogel for Triggering Immunotherapy